Legalon 70 during Pregnancy

Experimental results indicate that silibin strongly inhibits hepatopacyte absorption of amatoxin by competitively inhibiting the same transport system (OATP1B3) during primary and enterohepatic circulation of the toxin [19, 20]. The latter mechanism is obviously relevant for human intoxication, since patients appear only long after the end of primary absorption. According to current knowledge on the toxicity of amatoxin, the period during which the transcription process remains blocked in hepatocytes is relevant for prognosis. This period is largely determined by the amount of amatoxins absorbed into the portal vein blood, either primarily or during enterohepatic circulation [2]. A substance such as silibinin, which can potentially lower the concentration of amatoxin on the target cell by blocking the transport system used by the amatoxin, is therefore promising. Legalon can be taken on an empty stomach; As this can result in the absorption of the active ingredient into the body faster. However, Legalon may also be taken with or after meals to prevent gastrointestinal discomfort, or as directed by your doctor. Legalon® SIL is generally well tolerated. No serious adverse reactions have been reported as part of pharmacovigilance and regular safety updates over the years since the product was launched in 1984. Flushing during intravenous therapy is not rarely reported, but appears to be of low degree.

In approximately 9,000 patients, estimated by product sales, infusion therapy with Legalon® SIL can be considered safe. Legalon is not recommended during pregnancy or breastfeeding, as there are no published studies proving its safe use during pregnancy or breastfeeding. Your doctor can discuss the risks and benefits of taking Legalon at these stages of life. The period between intoxication and the start of treatment, as well as the wide range of supportive measures needed, can vary greatly from patient to patient, making structured clinical trials virtually impossible. Therefore, clinical observations during pharmacovigilance studies are considered the only reasonable approach to collect data on the efficacy and tolerability of antidote candidates against amartoxin poisoning. About 60% of absorbed amatoxin is excreted in bile and undergoes enterohepatic circulation [14]. Therefore, the exposure of liver cells to toxins is prolonged. Kinetic studies in humans have shown that amatoxin is detectable in plasma at low concentrations within 24 to 48 hours of ingestion. No correlation could be found between plasma amatoxin concentrations and clinical severity or post-intoxication outcomes [13]. The toxin is excreted in the urine and can be detectable up to 3 to 4 days after ingestion. Work is underway to develop a clinically useful rapid diagnostic kit [9].

While fatal mushroom poisoning has long been recognized as a major health problem in Europe, the collection and consumption of wild mushrooms is popular among some immigrants as well as mushroom enthusiasts in the United States, resulting in a growing health risk [1, 2]. Despite warnings, edible and poisonous mushrooms such as Amanita phalloides are often confused with mushroom pickers. In rare cases, Amanita mushrooms have been ingested during suicide attempts [3]. The finer details of our medications help ensure that you can be sure that you are taking a reliable health product. What you see in clinical trials is what you get in our products. Silymarin 200 mg PO TID in combination with conventional treatment Participating in a study is an important personal decision. Talk to your doctor and family members or friends about the decision to participate in a study. To learn more about this study, you or your doctor can contact the study`s research staff using the contacts below. For general information, see About clinical trials.

In health food stores and pharmacies, you can find Legalon in the professional services section or near the pharmacy counter. If you prefer to find it near you, click the Find Flordis button above and follow the instructions, you can find a list of nearby places that carry Legalon or know how to order it. Even if your local pharmacy or health food store isn`t on the list, most can order it for customers upon request. bAbt. of Family Medicine, Dominican Hospital, Santa Cruz, CA 95076, USA By supporting normal excretory processes in the body1,3,4 After exposure to amatoxin, cells suffer from a lack of transcription information, which leads to a lack of essential proteins and possibly cell death. The decisive factor for cell survival is the length of time that amatoxins are present at a concentration sufficient to inhibit the transcription process (≥ 10-8 M), which in turn depends on the concentration of amatoxin in the extracellular medium [9]. There are currently more than 1,300 documented cases supporting the clinical efficacy of silibinin-based SIL Legalon® as an antidote in patients with acute amatoxin poisoning. This represents the largest patient population ever analyzed for this life-threatening poisoning. The all-cause mortality rate in patients treated with Legalon® SIL, regardless of the severity of liver injury, is less than 10%. This represents a reduction in the reported mortality rate of more than 50% before Legalon® SIL is available. Legalon® SIL can be used safely with a positive benefit-risk ratio.

Presence of metabolic syndrome, defined as the presence of at least 3 out of 5 of the following: Legalon supports liver health to relieve fatigue, weakness and fatigue, support anti-inflammatory processes, reduce abdominal fullness and relieve nausea. Case reports of 154 amatoxin-intoxicated patients treated with Legalon® SIL between 1983 and 1992 were evaluated for efficacy and tolerability (unpublished). All patients received Legalon® SIL as monotherapy (N=28) or in addition to penicillin (N=126). Intoxication trends and mortality rates were assessed for both treatment regimens. The diagnosis was confirmed in most patients by gastrointestinal symptoms, clinical presentation and fungal identification. Analysis of patient outcomes concluded that the all-cause mortality rate for a total of 154 patients was 9.7%, confirming the mortality reduction mentioned above. Treatment with Legalon® SIL was correlated not only with lower mortality, but also with a smaller increase in transaminases and less severe coagulopathy. There was only one death (4%) in the Legalon SIL monotherapy group, while 14 patients died in the Legalon®® SIL plus penicillin group (11%). Alcoholic liver disease, appetite stimulants, gallbladder problems, cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug induced), jaundice, pleurisy, prostate cancer, spleen diseases aResearch and development, Rottapharm | Madaus, Madaus GmbH, 51011 Cologne, Germany It is estimated that there are 100 to 200 deaths from mushroom poisoning each year in the United States and Europe [6]. Entries and exits of other genera containing amatoxin such as Lepiota and Galerina have also been reported [7, 8]. Medicines containing naturally occurring active ingredients such as Silybum marianum can vary greatly depending on the plant species chosen, the cultivation and harvest, as well as the extraction and production process.

Therefore, it is important to ensure that the final product you receive is the same as the one that has been researched in clinical trials. From kinetic studies in dogs and humans, it is known that amatoxin is easily absorbed by the intestinal epithelium, does not bind albumin and disappears rapidly from plasma [12, 13]. Legalon takes care to use the same specific extract of milk thistle, known as MZ 80, produced in a patented production process and studied in clinical trials to support healthy liver function.1-8 Antioxidant, protects hepatocyte membranes, improves liver parenchyma regeneration, increases glutathione levels Specific extract of Silybum marianum (milk thistle) (MZ 80) 180 mg equivalent.